Progress in studies of angiostatin and its anti-tumor effects

Authors
Yang, H Wu, Y Li, YX Ma, TH Huang, BQ
Citation
H. Yang et al., Progress in studies of angiostatin and its anti-tumor effects, CHIN SCI B, 46(6), 2001, pp. 454-460
Citations number
38
Categorie Soggetti
Multidisciplinary
Journal title
CHINESE SCIENCE BULLETIN
ISSN journal
10016538 → ACNP
Volume
46
Issue
6
Year of publication
2001
Pages
454 - 460
Database
ISI
SICI code
1001-6538(200103)46:6<454:PISOAA>2.0.ZU;2-0
Abstract
Angiostatin is a 38 ku circulating angiogenesis inhibitor purified from the serum and urine of mice bearing a murine Lewis lung carcinoma. It is regar ded as an internal fragment of plasminogen containing tile first 4 Kringle structures. In vitro, angiostatin specifically inhibits endothelial cell pr oliferation. In vivo, it inhibits angiogenesis and suppresses the growth of such primary tumors as Lewis lung carcinoma and hemangioendotheliolma in m ice.