J. Neilson et al., Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling, CURR OP IM, 13(3), 2001, pp. 346-350
Recent structural studies have supported a kinetic model of TCR activation,
raising the question of how the duration of receptor occupancy is translat
ed into activation of immune response genes. We summarize evidence that the
cytoplasmic-to-nuclear shuttling of NF-ATc family members monitors the dur
ation of receptor occupancy.