Polymorphism screening of four genes encoding advanced glycation end-product putative receptors - Association study with nephropathy in type 1 diabetic patients

Advanced glycation end-products (AGEs) may play an important role in the pa thogenesis and progression of cardiovascular and renal complications of dia betes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. in this study, me scanned the sequence of the genes encodi ng these AGE receptors in 48 patients with type 1 diabetes and investigated the identified polymorphisms (n = 19) in 199 type 1 diabetic patients with nephropathy and 193 type 1 diabetic patients without nephropathy. Overall, none of the polymorphisms was strongly associated with nephropathy The min or allele of a polymorphism located in the promoter region of the RAGE gene (C-1152A) conferred a weak protective effect (P < 0.05) and Was associated with a longer duration of nephropathy-free diabetes (P = 0.08).