The intramolecular ligand-exchange reaction of (SP-4-2)-dichlorobis-(2-hydroxyethylamine)platinum(II) and (OC-6-22)-tetrachlorobis-(2-hydroxyethylamine)platinum(IV), a H-1 and N-15,H-1-HMQC NMR study

The bis(ethanolamine)platinum complexes (SP-4-2)-dichlorobis (2-hydroxyethy lamine)platinum(II) (1) and (OC-6-22)- tetrachlororbis(2 -hydroxyethylamine ) platinum(IV) (2) have been synthesized and their chemistry in aqueous sol ution has been investigated due to the fact that 1 forms very stable monoad ducts with 5'-GMP. In water 1 and 2 are converted into (SP-4-3)-chloro(2-et hanolatoamine-kappa N-2,O)(2-hydroxy-ethylamine)platinum(II) (3) and (OC-6- 31)-trichloro(2-ethanol-ato amine-kappa N-2,O) (2 -hydroxyethylamine) plati num(IV) (4) with a chelating ethanolatoamine Ligand by a intramolecular lig and exchange reaction, which was confirmed by H-1 and 2D 15N,H-1-HMQC NMR e xperiments and the crystal structure determination of 4.