Increased risk for cancer in multiple myeloma patients and their first-degree relatives

Citation
J. Varkonyi et al., Increased risk for cancer in multiple myeloma patients and their first-degree relatives, HAEMATOLOGI, 31(1), 2001, pp. 45-50
Citations number
9
Categorie Soggetti
Hematology
Journal title
HAEMATOLOGIA
ISSN journal
00176559 → ACNP
Volume
31
Issue
1
Year of publication
2001
Pages
45 - 50
Database
ISI
SICI code
0017-6559(2001)31:1<45:IRFCIM>2.0.ZU;2-T
Abstract
Analyzing data of 125 multiple myeloma patients, the authors found a 40-fol d increased tumor incidence among the patients and their first-degree relat ives as compared to the average population. These tumors were the same as t hose usually found among Hungarians. There was no difference as to the pati ent's blood group antigens in the families of myeloma patients with or with out other rumor. IEA-type disease was found to be relatively more frequent in the group of patients who had tumor besides myeloma. In a prospective st udy, authors could not find mutation of suppressor gene p53 in 14 patients and their 16 healthy first-degree relatives. This may indicate that there i s no p53 suppressor gene alteration responsible for the high-risk condition for tumorgenesis in this population.