Assessing and managing the ecological risks from multiple stressors is beco
ming increasingly important as our environmental and regulatory focus moves
from managing point sources to one of managing and trading risks from mult
iples sources over large geographic areas. There are important corollaries
to this shift in focus and scale, one is the increased role and importance
of non-chemical stressors in shaping and controlling ecological systems, th
e fact that these categories of stress are, for the most part, not regulate
d under the traditional legislative mandates, that we have limited knowledg
e regarding the interaction of chemical and non-chemical stressors, that at
large scales we are faced with the integration of and trading of risks to
multiple resource categories. This trend of increased attention to regional
-scale environmental issues requires the development of new analysis and in
terpretive strategies and highlight the need for a systematic framework for
addressing the ecological effects of multiple stressors at regional ecolog
ical scales. We propose that such a framework have three essential properti
es: it be risk-based; it be effects driven; and it have the flexibility to
be used in both a retrospective and prospective manner. While several appro
aches have been proposed we believe that an ecological risk assessment fram
ework satisfies these criteria, has been used successfully in regional asse
ssments, and can readily be modified and adapted to serve a wide variety of
problem settings.