REPRODUCTIVE TOXICOLOGIC INVESTIGATIONS O N ADULT MALE-RATS OF THE STOCK WIST LPPT AFTER ORAL APPLICATION OF CADMIUM FOR EFFECT LEVEL DETECTION/

The reproductive-toxic effects after an oral administration of Cadmium as Cadmium chloride on testes and epididymidis of mature Wistar rats were investigated. After daily dosages of 0.3, 0.6, 1.0 oder 2.0 mg Cd Cl2/kg b. w. over one or two weeks no changes of testes and epididymid is were detected in comparison with control animals by histological ob servations. By means of morphometrical methods significant changes of the testes from a dosage of 1.0 mg/kg b. w. and changes of the epididy midis previously a dosage of 0.3 mg/kg b. w. have been demonstrated. T hat means the effect level of Cadmium is higher by consideration of te stes than of epididymidis. Consequently, during investigations of repr oductive toxicity one hand to test both organs.