As. Alhomida, STUDY OF THE EFFECTS OF THEOPHYLLINE-RELATED CHANGES IN TOTAL, FREE, SHORT-CHAIN ACYL AND LONG-CHAIN ACYL CARNITINE CONCENTRATIONS IN RAT-HEART, Toxicology, 121(3), 1997, pp. 205-213
This study is conducted to investigate the effect of oral theophylline
administration on total (TC), free (FC), short-(SC), long-chain acyl
(LC), acyl (AC) carnitine concentrations and acyl to free carnitine (A
C/FC) ratio in rat heart. Theophylline was administrated at 100 mg/kg
wt/day, and effects were monitored after a treatment period that laste
d between a week and five weeks. The results indicated that theophylli
ne feeding leads to significantly higher concentrations of TC, FC, SC,
LC and AC in heart tissue as compared to those of control and placebo
groups (P < 0.001). Moreover, the ratio of AC/FC was significantly in
creased (P < 0.001) as compared to either control or placebo groups. T
hese changes may result from theophylline-enhanced mobilization of lip
ids from adipose tissues, which consequently stimulates an increased c
arnitine transport into the heart tissues to form fatty acylcarnitines
for subsequent beta-oxidation inside the heart mitochondria. (C) 1997
Elsevier Science Ireland Ltd.