This paper presents an optimization-based method for selecting manipulated
variables for regulatory control schemes. The objective of this mathematica
l programming technique is the minimization of the overall interaction and
sensitivity of the closed-loop system to disturbances. In addition, a gener
al methodology for incorporating qualitative knowledge as linear constraint
s to the problem is demonstrated. The main advantage of the method is that
the plantwide nature of the problem is preserved, because decisions related
to different levels of the base regulatory control scheme are made simulta
neously. The usefulness of the method is demonstrated using a double-effect
evaporator case study, the hydrodealkylation of toluene case study, and th
e Tennessee Eastman challenge problem.