The effect of topically applied vasoactive agents and testosterone versus testosterone in the treatment of erectile dysfunction in aged men with low sexual interest
A. Gomaa et al., The effect of topically applied vasoactive agents and testosterone versus testosterone in the treatment of erectile dysfunction in aged men with low sexual interest, INT J IMPOT, 13(2), 2001, pp. 93-98
The objective was to evaluate the efficacy and safety of topically applied
cream containing testosterone, isosorbide dinitrate and co-dergocrine mesyl
ate compared to testosterone cream in the treatment of erectile dysfunction
in aged men with low sexual interest. A randomised double-blind crossover
trial was performed over two months. The subjects were 42 men with erectile
dysfunction and low normal or slightly depressed testosterone level random
ly allocated to two equal groups. Polypharmacy cream containing testosteron
e 0.8%, isosorbide dinitrate 0.5% and co-dergocrine mesylate 0.06% was appl
ied for one month, and testosterone 0.8% cream for another month. The serum
level of total testosterone was measured before and after each phase of tr
eatment. Response to each therapy was assessed by a sexual questionnaire, m
easurement of tumescence and repeat penile duplex ultrasonography, Twenty-e
ight patients reported full erection and satisfactory intercourse with the
polypharmacy cream. Thirteen men reported full erection and satisfactory in
tercourse with either cream. Polypharmacy cream increased penile arterial d
ow (P < 0.001) and induced tumescence in 34 patients in lab. No patient in
either phase of the study has tumescence or a significant increase in caver
nous arterial peak systolic velocities after the application of testosteron
e cream. Serum level of total testosterone increased in all patients (P < 0
.05), Sexual desire was improved in 85% and 62% of patients during the trea
tment with polypharmacy cream and testosterone cream, respectively, No mark
ed side effects were reported after either of them. Topical treatment with
cream containing testosterone and vasoactive agents may represent a new eff
ective treatment for erectile dysfunction associating with aging.