Significant differences between Yemenite and Egyptian STR profiles and theinfluence on frequency estimations in Arabs

A population genetic study was performed on Yemenites using the set of nine short tandem repeat loci (STRs) D3S 1358, VWA, FGA, D8S1179, D21S11, D18S5 1, D5S818, D13S317 and D7S820. Analysis of the data revealed that all loci were in Hardy-Weinberg equilibrium and evidence of linkage equilibrium was found for only 1 out of 36 locus pairs. At seven loci the allelic distribut ions found in the Yemenite sample were significantly different from those f ound for an Arab population sample from Egypt. Nevertheless, we assume that the Yemenite database can be used for Arabs of unknown or foreign (non-Yem enite) origin in the absence of population-specific databases without exert ing a significant bias on the biostatistical interpretation. In an experime ntal set-up (ethnic profile frequency ratio test), the impact of calculatin g multi-locus profile frequencies for foreign Arab individuals (Egyptians) using the Yemenite database instead of a region-specific one was negligible .