Radiofrequency is performed with thin electrodes that are placed in the cen
ter of a tumor under ultrasonographic guidance. Radiofrequency waves induce
ionic agitation which destroys neighboring tissues by heat. The most recen
t equipment can produce necrosis of 4-cm diameter areas. Efficacy is enhanc
ed by blocking intrahepatic blood flow which naturally refreshes the liver
parenchyma. The technique has the advantage of minimal invasion and of spar
ing liver parenchymal tissue. radiofrequency can be performed percutaneousl
y or by laparoscopi or laparotomy. results in most reported series have bee
n good with low morbidity. rapid improvment of material and of new associat
ed procedures (vascular clamping, cooling infusion of the bile ducts, trans
plaeurodiaphragmatic approach, combination with other new approaches in liv
er surgery) are continuously modifying performance levels and potential ind
ications curently under validation. radiofrequency, like other tools for lo
cal tumor destruction, will greatly change our therapeutic strategies in th
e neat future.