Positron omission tomography with 2-[18F]-fluoro-2-deaxy-D-glucose in oncology Part IIIa: Therapy response monitoring in breast cancer, lymphoma and gliomas

Positron emission tomography (PET! using F-18-fluorodeoxyglucose (FBG) is c onsidered to be a very useful adjunct to anatomic imaging techniques and is now primarily used for oncological indications. These indications include diagnosis, staging, and therapy monitoring. In this review, we discuss the articles in which FDG-PET is clinically used for monitoring therapy in brea st cancer, lymphomas and gliomas. It is found that the amount of FDG uptake strongly correlates with response to therapy in breast cancer, lymphomas, and gliomas; a decrease in FDG uptake after therapy indicates a positive re sponse to therapy. However, this conclusion is based on small patient numbe rs, whereas the exact response mechanism is still unknown. Therefore, more studies in comparable patient groups are required to achieve a better under standing of FDG uptake patterns after therapy. Part IIIb deals with lung, a nd head and neck cancer, hepatocellular and colorectal tumours, and sarcoma .