Synthesis of chiral fused heterocyclic compounds containing 1,2,4-triazolering

Authors
Wang, ZY Shi, HX Shi, HJ
Citation
Zy. Wang et al., Synthesis of chiral fused heterocyclic compounds containing 1,2,4-triazolering, J HETERO CH, 38(2), 2001, pp. 355-357
Citations number
12
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
38
Issue
2
Year of publication
2001
Pages
355 - 357
Database
ISI
SICI code
0022-152X(200103/04)38:2<355:SOCFHC>2.0.ZU;2-2
Abstract
A series of new chiral (S)-3-aryl-6-pyrrolidin-2-yl-[1,2,4]triazolo[3,4-b]t hiadiazole (II1-5), (S)-1-(3-aryl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6- yl)-ethylamine (II6-8) and (S)-1,2-bis(3-aryl-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazol-6-yl)-ethylamin (II9-11) were prepared by the condensation of 3- aryl-4-amino-5-mercapto-1,2,4-triazoles with different L-amino acids in the presence of phosphorus oxychloride and evaluated for their antibacterial a ctivity.