Synthesis of substituted pyrimido[4,5-b] and [5,4-c]-[1,8]naphthyridines

Authors
Plisson, C Chenault, J
Citation
C. Plisson et J. Chenault, Synthesis of substituted pyrimido[4,5-b] and [5,4-c]-[1,8]naphthyridines, J HETERO CH, 38(2), 2001, pp. 467-470
Citations number
7
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
38
Issue
2
Year of publication
2001
Pages
467 - 470
Database
ISI
SICI code
0022-152X(200103/04)38:2<467:SOSPA[>2.0.ZU;2-U
Abstract
Ethyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro[1,8]napthyridine-3-carboxylate (1) , precursor of nalidixic acid, has been converted in two steps through ([1, 8]naphthyridin-3-yl)carbonylguanidin derivatives into substituted pyrimido[ 4,5-b] and [5,4-c][1,8]naphthyridines.