Mucinous adenocarcinoma arising in a neovagina using the sigmoid colon thirty years after operation: A case report

Background: Because of a relative rarity of the cases with an artificial va gina, the incidence of a case with malignant disease arising in the neovagi na is extremely rare. A case of adenocarcinoma arising from a neovagina is presented with a review of the literature. Case: A neovagina was constructed using the sigmoid colon at the age of 23 for congenital agenesis of the vagina, Rokitansky-Kuster-Hauser syndrome. S ubsequently, the patient had regular sexual intercourse for about 20 years. At the age of 53, she came to our outpatient clinic with a complaint of va ginal bleeding, and adenocarcinoma was found at the anterior wall of the ne ovagina adjoining the introitus. Total resection of the neovagina and adjuv ant radiotherapy was performed. The pathological diagnosis was mucinous ade nocarcinoma. Conclusions: In view of relatively low incidence of mucinous carcinoma aris ing in the sigmoid colon along with the ectopic localization, this case may have implications for the understanding of pathogenesis of sigmoid colon c ancer. (C) 2001 Wiley-Liss, Inc.