Skin and nail changes from long-term hydroxyurea therapy are reported in ad
ults. Skin and nail changes, including nail hyperpigmentation, longitudinal
bands, and hyperpigmentation of the palms and other skin surfaces, develop
ed in 7 children with sickle cell anemia after 6 to 16 weeks of hydroxyurea
therapy. Cutaneous and nail changes may occur in children receiving hydrox
yurea.