Electrophysiologic characteristics in initiation of paroxysmal atrial fibrillation from a focal area

OBJECTIVES We investigated the electrophysiologic characteristics in the in itiation of paroxysmal atrial fibrillation (PAF) from a focal area. BACKGROUND The electrophysiologic characteristics in the initiation of PBF are still not clear. METHODS The study group consisted of 77 patients (M/F = 65/12, age 66 +/- 1 2 years) with frequent episodes of PAF; we analyzed: 1) 15 cycle lengths of electrical activity before the onset of atrial fibrillation (AF); 2) coupl ing interval (CI) of the first ectopic beat just before the initiation of A F: and 3) the prematurity; of an ectopic beat (prematurity index [PI] = CI/ mean of preceding 15 cycle lengths). RESULTS A total of 111 episodes of sustained AF were identified, Two patter ns of AF initiation were observed: group I (59/111, 53%) included the episo des preceded bu cycle length oscillation, and group II (52/111, 47%) includ ed the episodes initiated by a single ectopic beat with preceding cycle. le ngth relatively constant. The PI of group I episodes was significantly grea ter than that of group II (0.41 +/- 0.12 vs. 0.34 +/- 0.10, p < 0.01). The CI (267 +/- 54 ms vs. 217 +/- 55 ms, p < 0.05), AF1 (194 +/- 36 ms rs. 153 +/- 37 ms, p < 0.05) and PI (0.49 +/- 0.13 ts. 0.37 +/- 0.11, p < 0.01) of the AF episodes from the superior vena cava (SVC) were significantly longer and greater than those of AF episodes from pulmonary veins (PVs). CONCLUSIONS In patients with PAF originating from PVs or the SVC, two major initiating patterns were found. Moreover, the electrophysiologic character istics in the initiation of AF originating from the SVC were also different from those of AF initiating from the PVs. (J Am Coll Cardiol 2001;37:1658- 64! (C) 2001 by the,American College of Cardiology.