Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation

Authors
Llorente, AM Van Gorp, WG Stern, MJ George, L Satz, P Marcotte, TD Calvillo, GM Hinkin, CH
Citation
Am. Llorente et al., Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation, J INT NEURO, 7(1), 2001, pp. 27-32
Citations number
32
Categorie Soggetti
Neurology
Journal title
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
ISSN journal
13556177 → ACNP
Volume
7
Issue
1
Year of publication
2001
Pages
27 - 32
Database
ISI
SICI code
1355-6177(200101)7:1<27:LEOHZT>2.0.ZU;2-C
Abstract
This study examined the treatment outcome of high-dose (1500 mg/day) zidovu dine (AZT) on neuropsychological (NP) functioning (Trailmaking Test A & B, WAIS-R Digit Symbol, and Rey Auditory Verbal Learning Test) across a 12-mon th period in mildly symptomatic HIV-L seropositive men (n = 46 at entry) en rolled in a randomized, double-blind, placebo-controlled trial (VA Cooperat ive Studies Program #298). Neither short-term (0-6 months) nor long-term (0 -12 months) AZT administration revealed enhancement in NP performance. The results suggest that, although AZT may afford patients prophylactic benefit s, protracted high-dose AZT treatment does not improve NP functioning in mi ldly symptomatic HIV-positive individuals.