Tl. Jernigan et al., Mesial temporal, diencephalic, and striatal contributions to deficits in single word reading, word priming, and recognition memory, J INT NEURO, 7(1), 2001, pp. 63-78
Citations number
83
Categorie Soggetti
Neurology
Journal title
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
Fifty-three volunteer participants were studied with the fade-in task (Oste
rgaard, 1998) to measure naming latency, word priming, and recognition-memo
ry performance, and with morphometric magnetic resonance imaging (MRI) tech
niques to measure volumes of mesial temporal lobe, diencephalic, striatal,
and neocortical structures. The relationship between measures of cerebral V
olume loss and performance deficits was modeled using simultaneous regressi
on analyses in which the behavioral measures were dependent variables. The
results suggested that damage in both hippocampal and amygdala/entorhinal a
reas as well as damage in the diencephalon and the nucleus accumbens all co
ntributed independently to the severity of recognition-memory deficits. Bot
h caudate nucleus damage and hippocampal damage contributed independently t
o increased naming latency (slowed single-word reading). Finally, only dama
ge in the hippocampus appeared to result in decreased word priming. These r
esults provide further evidence against the assertion that word priming rep
resents a form of memory unaffected by damage to the mesial temporal lobes.