Genetic toxicology of a paradoxical human carcinogen, arsenic: a review

Arsenic is widely distributed in nature in air, water and soil in the form of either metalloids or chemical compounds. It is used commercially, as pes ticide, wood preservative, in the manufacture of glass, paper and semicondu ctors. Epidemiological and clinical studies indicate that arsenic is a para doxical human carcinogen that does not easily induce cancer in animal model s. It is one of the toxic compounds known in the environment. Intermittent incidents of arsenic contamination in ground water have been reported from several parts of the world. Arsenic containing drinking water has been asso ciated with a variety of skin and internal organ cancers. The wide human ex posure to this compound through drinking water throughout the world causes great concern for human health. In the present review, we have attempted to evaluate and update the mutagenic and genotoxic effects of arsenic and its compounds based on available literature. (C) 2001 Elsevier Science B.V. Al l rights reserved.