A virus finds its natural killer

Authors
Casanova, JL Jouanguy, E Abel, L
Citation
Jl. Casanova et al., A virus finds its natural killer, NAT GENET, 28(1), 2001, pp. 7-9
Citations number
15
Categorie Soggetti
Molecular Biology & Genetics
Journal title
NATURE GENETICS
ISSN journal
10614036 → ACNP
Volume
28
Issue
1
Year of publication
2001
Pages
7 - 9
Database
ISI
SICI code
1061-4036(200105)28:1<7:AVFINK>2.0.ZU;2-R
Abstract
It has been suggested that natural killer (NK) cells contribute to host def ense against infections, but genetic evidence has been lacking. A new study of mouse strains susceptible to infection by cytomegalovirus indicates tha t the Klra8 (formerly Ly49H) stimulatory receptor is essential to resisting the virus. Such a receptor may have evolved as a response of NK cells to v iral strategies to evade the immune system.