H. Matsuoka et al., ANTIRHEUMATIC AGENTS .3. NOVEL METHOTREXATE DERIVATIVES BEARING AN INDOLINE RING AND A MODIFIED ORNITHINE OR GLUTAMIC-ACID, Chemical and Pharmaceutical Bulletin, 45(7), 1997, pp. 1146-1150
The synthesis, biological profile and structure-activity relationship
of various methotrexate (MTX) derivatives bearing an indoline ring are
described. In particular, in-6-yl)-methyl]indoline-5-ylcarbonyl]-L-gl
utamine (3d), compared to MTX, exhibited an enhanced anti-proliferativ
e effect on human peripheral blood mononuclear cells obtained from hea
lthy volunteers.