ANTIRHEUMATIC AGENTS .3. NOVEL METHOTREXATE DERIVATIVES BEARING AN INDOLINE RING AND A MODIFIED ORNITHINE OR GLUTAMIC-ACID

Authors
MATSUOKA H KATO N OHI N MIYAMOTO K MIHARA M TAKEDA Y
Citation
H. Matsuoka et al., ANTIRHEUMATIC AGENTS .3. NOVEL METHOTREXATE DERIVATIVES BEARING AN INDOLINE RING AND A MODIFIED ORNITHINE OR GLUTAMIC-ACID, Chemical and Pharmaceutical Bulletin, 45(7), 1997, pp. 1146-1150
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
7
Year of publication
1997
Pages
1146 - 1150
Database
ISI
SICI code
0009-2363(1997)45:7<1146:AA.NMD>2.0.ZU;2-A
Abstract
The synthesis, biological profile and structure-activity relationship of various methotrexate (MTX) derivatives bearing an indoline ring are described. In particular, in-6-yl)-methyl]indoline-5-ylcarbonyl]-L-gl utamine (3d), compared to MTX, exhibited an enhanced anti-proliferativ e effect on human peripheral blood mononuclear cells obtained from hea lthy volunteers.