ENANTIOMER-DIFFERENTIATING ABILITY OF CYCLO(L-PHE-L-PRO)(4) HAVING A RIGID SKELETON FOR PHENYLALANINE METHYLESTER HYDROCHLORIDE

Authors
ISHIZU T NOGUCHI S
Citation
T. Ishizu et S. Noguchi, ENANTIOMER-DIFFERENTIATING ABILITY OF CYCLO(L-PHE-L-PRO)(4) HAVING A RIGID SKELETON FOR PHENYLALANINE METHYLESTER HYDROCHLORIDE, Chemical and Pharmaceutical Bulletin, 45(7), 1997, pp. 1202-1204
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
7
Year of publication
1997
Pages
1202 - 1204
Database
ISI
SICI code
0009-2363(1997)45:7<1202:EAOCHA>2.0.ZU;2-6
Abstract
The formation constant of the 1:1 complex of cyclo(L-Phe-L-Pro)(4) (1) with L-PheOMe . HCl was about 13.2 times that of the complex with D-P heOMe . HCl. The 1:1 comples of 1 with L-PheOMe . HCl formed three int ermolecular hydrogen bonds between Pro(2)CO, Phe(1)CO and the amino gr oup, and Phe(2)NH and the carbonyl group, whereas that with D-PheOMe . HCl formed only one between Phe(1) CO and the amino group.