The first total synthesis of (+/-)-linderol A, a tricyclic hexahydrodibenzofuran constituent of Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells

Authors
Yamashita, M Ohta, N Kawasaki, I Ohta, S
Citation
M. Yamashita et al., The first total synthesis of (+/-)-linderol A, a tricyclic hexahydrodibenzofuran constituent of Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells, ORG LETT, 3(9), 2001, pp. 1359-1362
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
9
Year of publication
2001
Pages
1359 - 1362
Database
ISI
SICI code
1523-7060(20010503)3:9<1359:TFTSO(>2.0.ZU;2-P
Abstract
[GRAPHICS] The first total synthesis of (+/-)-linderol A, a hexahydrodibenzofuran isol ated from Lindera umbellata bark, with potent inhibitory activity on melani n biosynthesis of cultured B-16 melanoma cells was achieved via a 20-step o f reaction in 7.64% overall yield starting from 4,6-dimethoxysalicylaldehyd e.