Absolute stereochemistry of amphidinolide C

Authors
Kubota, T Tsuda, M Kobayashi, J
Citation
T. Kubota et al., Absolute stereochemistry of amphidinolide C, ORG LETT, 3(9), 2001, pp. 1363-1366
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
9
Year of publication
2001
Pages
1363 - 1366
Database
ISI
SICI code
1523-7060(20010503)3:9<1363:ASOAC>2.0.ZU;2-T
Abstract
[GRAPHICS] The absolute configurations at 12 chiral centers in amphidinolide C (1), a potent cytotoxic 25-membered macrolide isolated from a marine dinoflagellat e Amphidinium sp,, were determined to be 3S, 4R, 6R, 7R, 8R, 12R 135, 16S, 20R, 23R, 24R, and 29S by combination of NMR analyses, degradation experime nts, and synthesis of the C-1-C-7 segment.