The societal consensus that has supported the United States' universal chil
dhood immunization programs for the past 50 years shows signs of eroding. T
his article proposes a systematic approach to evaluate immunization policy
options. Through a unifying framework that combines epidemiologic, economic
, and ethical concerns, this approach promotes a clearer understanding of u
nderlying issues and inherent tradeoffs between alternative policies. Such
a systematic examination of policy options could facilitate the public dial
ogue necessary to continually recreate a broad consensus on immunization pr
actices and enable us to choose policies most in accord with our fundamenta
l values.