Exploring the domain structure of modular nonribosomal peptide synthetases

Authors
Weber, T Marahiel, MA
Citation
T. Weber et Ma. Marahiel, Exploring the domain structure of modular nonribosomal peptide synthetases, STRUCTURE, 9(1), 2001, pp. R3-R9
Citations number
38
Categorie Soggetti
Biochemistry & Biophysics
Journal title
STRUCTURE
ISSN journal
09692126 → ACNP
Volume
9
Issue
1
Year of publication
2001
Pages
R3 - R9
Database
ISI
SICI code
0969-2126(20010110)9:1<R3:ETDSOM>2.0.ZU;2-F
Abstract
Recently, considerable insight has been gained into the modular organizatio n of nonribosomal peptide synthetases (NRPS). The three-dimensional structu res of domains associated with substrate adenylation and covalent binding h ave been solved as well as the structure of a priming enzyme required for t he post-translational modification of NRPS. Taken together, these studies w ill help us to understand the architecture of these mega-enzymes.