Stereoselective inclusion and structure of equatorial-trans-1,2-dichlorocyclohexane

Optically active (R, R)-(-)-trans-1,2-dichlorocyclohexane (DCC) was isolate d as an inclusion crystal with the optically active host, 2,3-(hydroxydiphe nylmethyl)-1,4-dioxaspiro[4.4]-no-nane, and the structure of the 2:1 inclus ion crystal has been determined by ii-ray analysis. Crystal data: C72H74O8C l2, orthorhombic, P2(1)2(1)2 (No. 18), a = 17.465(6) Angstrom, b = 20.095(6 ) Angstrom, c = 8.664(5) Angstrom, V = 3040(2) Angstrom (3), Z = 2, D-c = 1 .24 g cm(-3), D-m = 1.23 g cm(-3), T = 293 K and final R-1 = 0.050 for 2766 observed data (I > 2 sigma (I)). The conformation of DCC in the inclusion crystal has been found to be equatorial and the absolute configuration was definitely determined to be (R, R) on the basis of the known configuration of the host.