Comparison between Roesy and C-13 NMR complexation shifts in deriving the geometry of inclusion compounds: A study on the interaction between hyodeoxycholic acid and 2-hydroxypropyl-beta-cyclodextrin

Authors
Mucci, A Schenetti, L Vandelli, MA Ruozi, B Salvioli, G Forni, F
Citation
A. Mucci et al., Comparison between Roesy and C-13 NMR complexation shifts in deriving the geometry of inclusion compounds: A study on the interaction between hyodeoxycholic acid and 2-hydroxypropyl-beta-cyclodextrin, SUPRAMOL CH, 12(4), 2001, pp. 427-433
Citations number
14
Categorie Soggetti
Chemistry
Journal title
SUPRAMOLECULAR CHEMISTRY
ISSN journal
10610278 → ACNP
Volume
12
Issue
4
Year of publication
2001
Pages
427 - 433
Database
ISI
SICI code
1061-0278(2001)12:4<427:CBRACN>2.0.ZU;2-W
Abstract
The formation and geometry of the hyodeoxycholic acid (HDCA)/ 2-hydroxyprop yl-beta -cyclodextrin (HP beta CD) complex in methanol-d(4) solution was de termined through a rotating frame nuclear Overhauser (ROESY) experiment. Th e reported results confirmed those independently and previously obtained th ough the use of C-13 complexation shifts in the same solvent. The C-13 appr oach, which needs shorter experimental times and is currently used in the s tudy of HP beta CD/bile acid systems, was then substantiated.