Amination of aryl halides using copper catalysis

Authors
Lang, FR Zewge, D Houpis, IN Volante, RP
Citation
Fr. Lang et al., Amination of aryl halides using copper catalysis, TETRAHEDR L, 42(19), 2001, pp. 3251-3254
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
19
Year of publication
2001
Pages
3251 - 3254
Database
ISI
SICI code
0040-4039(20010507)42:19<3251:AOAHUC>2.0.ZU;2-6
Abstract
Bromopyridine 4 was converted into aminopyridine 5 under Cu2O catalysis wit h an ethylene glycol solution of ammonia in excellent yield (90%). The amin ation reaction features low (0.5 mol%) catalyst loading, mild reaction temp erature (80 degreesC) and low reaction pressure (50 psi). This protocol is further studied in the amination of a variety of aryl halides. (C) 2001 Els evier Science Ltd. All tights reserved.