New polyoxyalkyleneamine-grafted paramagnetic supports for solid-phase synthesis and bioapplications

The synthesis of some novel polyoxyalkyleneamine grafted paramagnetic suppo rts for use in chemical and biological applications is described. These com posite supports were synthesized by utilizing power ultrasound to enhance t he level of incorporation of certain high molecular weight, polyoxyalkylene amine (Jeffamine(R)) polymers into the matrix of a chloromethylated paramag netic support. These new composite paramagnetic supports show excellent exp ansion properties in both organic solvents and water. The use of these graf ted supports for multi-step solid-phase synthesis was then demonstrated by example. (C) 2001 Elsevier Science Ltd. All rights reserved.