A new method for the synthesis of N-protected allyl- and homoallylglycines
was developed from aspartic and glutamic acid derivatives. The carboxylic s
ide-chains of aspartic and glutamic derivatives was first transformed into
the Weinreb amide by coupling with N,O-dimethylhydroxylamine and then reduc
ed into the corresponding aldehyde. The latter could react with methyl-trip
henylphosphonium bromide to yield the title compounds with 50% total yield.
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