T. Hottop et al., Synthesis of 4-demethoxyadriamycinone utilizing ruthenium-catalyzed oxidation of allyl acetates, TETRAHEDR L, 42(19), 2001, pp. 3343-3346
A new method for the construction of the side chain of anti-cancer drugs ad
riamycins is demonstrated by the synthesis of 4-demethoxyadriamycinone. The
key step is the ruthenium-catalyzed oxidation of allyl acetates to the cor
responding alpha -hydroxyketones. (C) 7001 Elsevier Science Ltd. All rights
reserved.