Synthesis of 4-demethoxyadriamycinone utilizing ruthenium-catalyzed oxidation of allyl acetates

Citation
T. Hottop et al., Synthesis of 4-demethoxyadriamycinone utilizing ruthenium-catalyzed oxidation of allyl acetates, TETRAHEDR L, 42(19), 2001, pp. 3343-3346
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
19
Year of publication
2001
Pages
3343 - 3346
Database
ISI
SICI code
0040-4039(20010507)42:19<3343:SO4URO>2.0.ZU;2-X
Abstract
A new method for the construction of the side chain of anti-cancer drugs ad riamycins is demonstrated by the synthesis of 4-demethoxyadriamycinone. The key step is the ruthenium-catalyzed oxidation of allyl acetates to the cor responding alpha -hydroxyketones. (C) 7001 Elsevier Science Ltd. All rights reserved.