Advances in structural and functional neuroimaging have allowed researchers
to study the neural correlates of aphasia. In general, nonfluent aphasias
are associated with left pre-rolandic lesions, and fluent aphasias occur wi
th left post-rolandic lesions that spare pre-rolandic areas. However, funct
ional neuroimaging studies have shown that neural dysfunction often extends
beyond the structural lesion. Recovery of aphasia is better when lesions s
pare frontal-subcortical white matter and temporal-parietal cortex. Functio
nal neuroimaging studies of aphasia recovery have indicated some right hemi
sphere activation, bur better recovery and response to treatment is associa
ted with increased left hemisphere activation in regions surrounding struct
ural lesions.