Genomic imprinting and cancer; new paradigms in the genetics of neoplasia

Authors
Schofield, PN Joyce, JA Lam, WK Grandjean, V Ferguson-Smith, A Reik, W Maher, ER
Citation
Pn. Schofield et al., Genomic imprinting and cancer; new paradigms in the genetics of neoplasia, TOX LETT, 120(1-3), 2001, pp. 151-160
Citations number
66
Categorie Soggetti
Pharmacology & Toxicology
Journal title
TOXICOLOGY LETTERS
ISSN journal
03784274 → ACNP
Volume
120
Issue
1-3
Year of publication
2001
Pages
151 - 160
Database
ISI
SICI code
0378-4274(20010331)120:1-3<151:GIACNP>2.0.ZU;2-6
Abstract
The role of epigenetic modification of gene expression is becoming increasi ngly important in how we under stand the loss of tumour suppressor gene fun ction in a variety of rumours and tumour predisposing syndromes. This revie w explores the importance of epimutation in Beckwith-Wiedemann syndrome and Wilms' tumour and focuses on genomic methylation in both imprinted and non -imprinted genes as a key mechanism in the development of cancer. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.