Fetal cardiac performance in uncomplicated and well-controlled maternal type I diabetes

Objective To study the impact of well-controlled, uncomplicated maternal di abetes on fetal cardiac development and performance. Methods The following variables were studied in 45 fetuses of type I diabet ic women by means of mid- and late-trimester echocardiography: interventric ular septal thickness; aortic and pulmonary value diameters; peak and time- to-peak flow velocity of the great arteries; the ratio between peak velocit ies during early (E) and late (A) ventricular filling at the level of the a trioventricular valves; ventricular fractional shortenings; and output. The findings were compared to age-matched control groups of normal fetuses. Results A significant augmentation of interventricular septal thickness was demonstrated for mid-trimester fetuses of diabetic women, which progressed further towards the end of pregnancy. However, the indices of diastolic an d systolic function remained comparable between the gestational age-matched groups. Conclusion Progressive myocardial thickening occurs commonly in mid- and la te-trimester fetuses of uncomplicated and well-controlled diabetic pregnanc ies. The observed degree of hypertrophy is generally mild and does not affe ct age-related changes in fetal cardiac function.