Relation between sodium-lithium countertransport and hypertriglyceridemia in type V hyperlipidemia

Citation
As. Wierzbicki et al., Relation between sodium-lithium countertransport and hypertriglyceridemia in type V hyperlipidemia, AM J HYPERT, 14(1), 2001, pp. 32-37
Citations number
30
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
AMERICAN JOURNAL OF HYPERTENSION
ISSN journal
08957061 → ACNP
Volume
14
Issue
1
Year of publication
2001
Pages
32 - 37
Database
ISI
SICI code
0895-7061(200101)14:1<32:RBSCAH>2.0.ZU;2-9
Abstract
Sodium-lithium countertransport (SLC) kinetics were measured in 30 patients with type V hyperlipidemia, 30 patients with type IIB hyperlipidemia on si milar treatment, and 30 age- and sex-matched healthy controls. Clinical and laboratory data including basic anthropometry and blood pressure were obta ined and blood was taken for detailed lipid biochemistry, glucose, insulin, and leptin measurements. Patients with type V hyperlipidemia were normoten sive but more obese than controls, had elevated triglycerides, very low-den sity lipoprotein, glucose, and insulin: and reduced HDL cholesterol compare d with type IIb controls. The median SLC activity (0.23 v 0.21 mmol Li+/L R BC/h) and median maximal velocity (0.33 v 0.31 mmol Li+/L RBC/h) were incre ased, but not significantly, compared to controls. In patients with type V hyperlipidemia SLC maximal velocity correlated with log triglycerides (r(2) = 0.853; P < .001) and log very low-density lipoprotein (VLDL) triglycerid es (r(2) = 0.947; P < .001). Sodium-lithium countertransport maximal veloci ty correlated weakly with the homeostasis model assessment index of insulin resistance (r(2) = 0.2241 P = .06). The sodium affinity of the transporter did not differ between the groups and was independent of any of clinical o r biochemical parameter studied. We conclude that VLDL triglyceride is stro ngly correlated with SLC maximal velocity and activity in patients with typ e V hyperlipidemia. (C) 2001 American Journal of Hypertension, Ltd.