Hk. Biesalski et Uc. Obermueller-jevic, UV light, beta-carotene and human skin - Beneficial and potentially harmful effects, ARCH BIOCH, 389(1), 2001, pp. 1-6
Solar radiation is one of the most important environmental stress agents fo
r human skin, causing sunburn, premature skin aging, and skin cancer. Beta-
carotene is discussed to protect against photooxidative stress and thus pre
vent skin damage. Though beta-carotene has been successfully used against p
hotosensitivity in patients with erythropoietic protoporphyria, its benefic
ial potential in normal skin is still uncertain. A number of experimental s
tudies indicate protective effects of beta-carotene against acute and chron
ic manifestations of skin photodamage. However, most clinical studies have
failed to convincingly demonstrate its beneficial effects so far. Neverthel
ess, intake of oral beta-carotene supplements before sun exposure has been
recommended on a population-wide basis. Recent studies on skin cells in cul
ture have revealed that beta-carotene acts not only as an antioxidant but a
lso has unexpected prooxidant properties. At present, there is an ongoing d
ebate on the protective or potentially harmful role of beta-carotene in hum
an skin. (C) 2001 Academic Press.