Bronchoconstriction following nebulised colistin in cystic fibrosis

Nebulised colistin is regularly used as antipseudomonal therapy in children with cystic fibrosis, We assessed bronchoconstriction in response to nebul ised colistin in 58 children. Nebulised colistin significantly reduced FEV1 , MEF25%, and Sao(2) for 15 minutes. In 20 children the reduction was great er than 10% from baseline FEV,, and was still at that level in five at 30 m inutes. Subjective assessment, baseline FEV1, and serum IgE were unable to identify susceptible children. It is recommended that children receiving co listin should be carefully assessed for bronchoconstriction.