Involvement of the central nervous system (CNS) is found in around 30% of c
hildren with haemolytic-uraemic syndrome (HUS). This complication is the si
ngle most common cause of mortality and also a major contributor to the mor
bidity associated with HUS. We reviewed 22 children with HUS and acute CNS
involvement. Both global and focal derangements occurred, and in survivors,
early regional EEG abnormalities-especially those in the occipital and tem
poral areas-were prognostically useful.