Lesions of the central nervous system often involve the pyramidal tracts an
d the sensory pathways to produce spasticity, paresthesias, and dysesthesia
. Three patients with intractable spasticity were treated with intrathecal
baclofen. Two had an implanted Medtronic SynchroMed pump for long-term deli
very of the muscle relaxant. The third patient had undergone a screening tr
ial in which the baclofen was delivered into the intrathecal space through
a lumbar catheter. All had excellent relief of spasms on clinical examinati
on, but they reported painful spasms particularly at night. Two of the pati
ents were successfully treated for dysesthesia.