Mm. Bilimoria et al., Underlying liver disease, not tumor factors, predicts long-term survival alter resection of hepatocellular carcinoma, ARCH SURG, 136(5), 2001, pp. 528-534
Hypothesis: A subset of patients can be identified who will survive without
recurrence beyond 5 years after hepatic resection for hepatocellular carci
noma (HCC).
Design: A retrospective review of a multi-institutional database of 591 pat
ients who had undergone hepatic resection for HCC and on-site reviews of cl
inical records and pathology slides.
Setting: All patients had been treated in academic referral centers within
university-based hospitals.
Patients: We identified 145 patients who had survived for 5 years or longer
after hepatic resection for HCC.
Main Outcome Measures: Clinical and pathologic factors, as well as scoring
of hepatitis and fibrosis in the surrounding liver parenchyma, were assesse
d for possible association with survival beyond 5 years and cause of death
among the 145 five-year survivors.
Results: Median additional survival duration longer than 5 years was 4.1 ye
ars. Women had significantly longer median additional survival durations th
an did men (81 months vs 38 months, respectively, after the 5-year mark) (P
=.008). Surgical margins, type of resection, an elevated preoperative alpha
-fetoprotein level, and the presence of multiple tumors or microscopic vas
cular invasion had no bearing on survival longer than 5) ears. However, pat
ients who survived for 5 years who also had normal underlying liver or mini
mal fibrosis (score, 0-2) at surgery had significantly longer additional su
rvival than did patients with moderate fibrosis (score, 3-4) or severe fibr
osis/cirrhosis (score, 5-6) (P < .001).
Conclusions: Death caused by HCC is rare beyond 5) ears after resection of
I-ICC in the absence of fibrosis or cirrhosis. The data suggest that chroni
c liver disease acts as a field of cancerization contributing to new HCC. T
hese patients may benefit from therapies directed at the underlying liver d
isease.