Synthesis of imidazo[1,2-a] pyridine derivatives as antiviral agents

Authors
Mavel, S Renou, JL Galtier, C Snoeck, R Andrei, G Balzarini, J De Clercq, E Gueiffier, A
Citation
S. Mavel et al., Synthesis of imidazo[1,2-a] pyridine derivatives as antiviral agents, ARZNEI-FOR, 51(4), 2001, pp. 304-309
Citations number
6
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN journal
00044172 → ACNP
Volume
51
Issue
4
Year of publication
2001
Pages
304 - 309
Database
ISI
SICI code
0004-4172(2001)51:4<304:SOIPDA>2.0.ZU;2-8
Abstract
The synthesis and antiviral activity of original dibromoimidazo[1,2-a]pyrid ines bearing a thioether side chain are reported. Molecular modeling was used to identify biophoric structural patterns that are common to 16 compounds. Structure-activity relationship (SAR) studies i dentified hydrophobicity (logP) as the most important factor for activity. From these SAR studies, the antiviral activity could be predicted.