Quinazolines as cyclin dependent kinase inhibitors

Authors
Sielecki, TM Johnson, TL Liu, J Muckelbauer, JK Grafstrom, RH Cox, S Boylan, J Burton, CR Chen, HY Smallwood, A Chang, CH Boisclair, M Benfield, PA Trainor, GL Seitz, SP
Citation
Tm. Sielecki et al., Quinazolines as cyclin dependent kinase inhibitors, BIOORG MED, 11(9), 2001, pp. 1157-1160
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
9
Year of publication
2001
Pages
1157 - 1160
Database
ISI
SICI code
0960-894X(20010507)11:9<1157:QACDKI>2.0.ZU;2-B
Abstract
Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspe cts of the SAR were investigated using solution-phase. parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined. (C) 2001 DuPon t Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights re served.