NAC/MEA conjugate: A new potent antioxidant which increases the GSH level in various cell lines

Authors
Oiry, J Mialocq, P Puy, JY Fretier, P Clayette, P Dormont, D Imbach, JL
Citation
J. Oiry et al., NAC/MEA conjugate: A new potent antioxidant which increases the GSH level in various cell lines, BIOORG MED, 11(9), 2001, pp. 1189-1191
Citations number
29
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
9
Year of publication
2001
Pages
1189 - 1191
Database
ISI
SICI code
0960-894X(20010507)11:9<1189:NCANPA>2.0.ZU;2-P
Abstract
I-152 is a prodrug of NAC and MEA with potent pro-GSH effects in human macr ophages, astrocytes and lymphocytes. This molecule could be of interest in HIV infection in respect to its antioxidant and anti-HIV activities, but al so in other diseases to counteract oxidative stress, that is, inflammation, cardiovascular diseases, and neurodegenerative diseases. (C) 2001 Elsevier Science Ltd. All rights reserved.