Antitumor agents. Part 204: Synthesis and biological evaluation of substituted 2-aryl quinazolinones

Authors
Xia, Y Yang, ZY Hour, MJ Kuo, SC Xia, P Bastow, KF Nakanishi, Y Nampoothiri, P Hackl, T Hamel, E Lee, KH
Citation
Y. Xia et al., Antitumor agents. Part 204: Synthesis and biological evaluation of substituted 2-aryl quinazolinones, BIOORG MED, 11(9), 2001, pp. 1193-1196
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
9
Year of publication
2001
Pages
1193 - 1196
Database
ISI
SICI code
0960-894X(20010507)11:9<1193:AAP2SA>2.0.ZU;2-I
Abstract
A series of 2 ' ,3 ' ,4 ' ,6,7-substituted 2-aryl quinazolinones were synth esized and evaluated for biological activity. Among them, 17 displayed sign ificant growth inhibitory action against a panel of tumor cell lines. Compo und 17 was also a potent inhibitor of tubulin polymerization. Compounds 8-1 0 displayed selective activity against P-gp-expressing epidermoid carcinoma of the nasopharynx. (C) 2001 Elsevier Science Ltd. all rights reserved.