Design and synthesis of 2-oxo-imidazolidine-4-carboxylic acid hydroxyamides as potent matrix metalloproteinase-13 inhibitors

Authors
Robinson, RP Laird, ER Donahue, KM Lopresti-Morrow, LL Mitchell, PG Reese, MR Reeves, LM Rouch, AI Stam, EJ Yocum, SA
Citation
Rp. Robinson et al., Design and synthesis of 2-oxo-imidazolidine-4-carboxylic acid hydroxyamides as potent matrix metalloproteinase-13 inhibitors, BIOORG MED, 11(9), 2001, pp. 1211-1213
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
9
Year of publication
2001
Pages
1211 - 1213
Database
ISI
SICI code
0960-894X(20010507)11:9<1211:DASO2A>2.0.ZU;2-Y
Abstract
A novel series of imidazolidinone-based matrix metalloproteinase (MMP) inhi bitors was discovered by structural modification of pyrrolidinone 1a. Poten t inhibition of MMP-13 was exhibited by the analogues having 4-(4-fluorophe noxy)phenyl (4a, IC50 = 3 nM) and 4-(naphth-2-yloxy)phenyl (4h, IC50 - 4 nM ) as Pl ' groups. (C) 2001 Elsevier Science Ltd. All rights reserved.