2-aryl indole NK1 receptor antagonists: Optimisation of indole substitution

Authors
Cooper, LC Chicchi, GG Dinnell, K Elliott, JM Hollingworth, GJ Kurtz, MM Locker, KL Morrison, D Shaw, DE Tsao, KL Watt, AP Williams, AR Swain, CJ
Citation
Lc. Cooper et al., 2-aryl indole NK1 receptor antagonists: Optimisation of indole substitution, BIOORG MED, 11(9), 2001, pp. 1233-1236
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
9
Year of publication
2001
Pages
1233 - 1236
Database
ISI
SICI code
0960-894X(20010507)11:9<1233:2INRAO>2.0.ZU;2-X
Abstract
The synthesis and biological evaluation of a series of 2-aryl indoles with high affinity for the human neurokinin-1 (hNK(1)) receptor are reported, co ncentrating on optimisation of the indole substitution. (C) 2001 Elsevier S cience Ltd, All rights reserved.