Design and pharmacology of quinuclidine derivatives as M-2-selective muscarinic receptor ligands

Authors
Bohme, TM Keim, C Dannhardt, G Mutschler, E Lambrecht, G
Citation
Tm. Bohme et al., Design and pharmacology of quinuclidine derivatives as M-2-selective muscarinic receptor ligands, BIOORG MED, 11(9), 2001, pp. 1241-1243
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
9
Year of publication
2001
Pages
1241 - 1243
Database
ISI
SICI code
0960-894X(20010507)11:9<1241:DAPOQD>2.0.ZU;2-W
Abstract
In our search for M-2-selective muscarinic receptor antagonists, we synthes ized 1,3-disubstituted indenes. The effects of different basic moieties wit h regard to binding and selectivity towards the five distinct muscarinic re ceptor subtypes were investigated. The results show that the quinuclidine s eries afforded the most promising compounds in terms of both receptor affin ity and M-2-subtype selectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.